The sustainable, compost friendly garden in AT&T baseball park. Yes, the compost comes from the remnants of each game. Yes, you see living towers filled with herbs, Yes, the herbs and veggies are used in the food at the park. Only in San Francisco. #sfgiants #attpark #baseball #mlb #garden #sustainable #ecological #ecofriendly #onlyinsanfrancisco #sanfrancisco (at At&T Park, Centerfield Bleachers)
A new microneedle patch, filled with dozens of tiny polymeric needles just 0.6 millimeters long, could provide pain-free injections.
In laboratory experiments, researchers showed that the microneedle patch could deliver lidocaine, a common painkiller, within five minutes of application.
In contrast, the drug in a commercial transdermal patch took 45 minutes to penetrate into the skin.
The shorter time for drug delivery is possible due to the miniature needles on the patch that create micrometer-sized porous channels in the skin when applied. The size of the patch could easily be adjusted to encapsulate different drug dosages.
Researchers, led by Kang Lifeng of National University of Singapore’s pharmacy department, report the pain-free and noninvasive technique in the journal Molecular Pharmaceutics.
This new way to administer painkillers quickly is good news for people who squirm at the sight of needles.
Team member Jaspreet Singh Kochhar says the research team tested the patch on themselves to confirm that the microneedles do not cause pain when applied to the skin. They only experienced a minor skin reddening as from being pinched.
The scientists also conducted a study that shows the microneedle patch delivers collagen to the dermis layer of the skin, unlike current skincare products that remain on the outermost skin layer. That work appeared in Pharmaceutical Research earlier this year.
Given the innovative technique for administering drug noninvasively, the patch can also be used in home-care settings. Patients could self-manage their pain arising from chronic diseases such as diabetes and cancer.
Moving forward, the researchers will test if the patch is useful for vaccinating young children, and for treating hair loss. For example, the patch can be applied to a baby’s arm five minutes before vaccination, so that the painkiller minimizes the pain from the subsequent jab.
The investigators have filed a patent for their technique through the NUS Industry Liaison Office. Kang Lifeng led the study.